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. Author manuscript; available in PMC: 2020 Jun 19.
Published in final edited form as: Nature. 2019 Jun 19;570(7762):514–518. doi: 10.1038/s41586-019-1310-4

Extended Data table 1 |.

GWAS Catalog heterogeneity by trait, including number of novel and secondary findings

Phenotype Largest GWAS catalog discovery population1 GWAS catalog tagSNPs best PAGE tagSNPs Novel
Loci
(count)6 		Secondary
Loci
(count)6
European East
Asian		 African Hispanic/
Latino		 PAGE Unique P<5×10−8 Het4 P<5×10−8 Het
5
Inflammatory Traits
CRP 66,185 10,112 8,280 3,548 28,537 82 38 7 16 1 0 0
WBC 19,509 33,231 16,388 - 28,534 27 10 5 11 3 1 1
MCHC 62,553 16,485 - 19,803 21 9 1 5 0 0 2
Platelet Count 48,666 14,806 7,943 12,491 29,328 92 23 0 28 0 1 1
Lipid Traits
HDL 99,900 12,545 7,917 4,383 33,063 244 71 8 21 1 2 2
LDL 94,595 12,545 7,861 4,383 32,221 192 46 12 18 0 0 2
TG 96,598 12,545 7,601 4,383 33,096 179 75 29 16 1 1 2
TC 100,184 8,344 6,480 4,383 33,185 166 31 4 20 0 1 2
Lifestyle Traits
Cigarettes/Day Excluding Nonsmokers 74,035 11,696 32,389 - 15,862 12 0 0 3 0 2 1
Coffee Cups/Day 91,462 - - - 35,902 16 3 1 3 0 1 0
Glycemic Traits
HbA1c 46,368 17,290 - - 11,178 29 8 1 9 0 1 3
Fasting Insulin 51,750 7,696 1,040 229 21,596 34 0 0 3 0 1 0
Fasting Glucose 58,074 24,740 2,029 4,176 23,963 55 15 3 7 0 2 0
Type II Diabetes2 12,171/56,862 15,463/26,183 1,264/5,678 3,848/4,366 14,075/31,752 286 28 2 13 0 0 1
Electrocardiogram Traits
QT Interval 71,061 6,805 13,105 - 17,348 183 39 1 11 0 0 2
QRS Interval 60,255 6,085 13,031 - 17,052 63 9 3 12 0 1 2
PR Interval 28,517 6,085 13,415 - 17,428 154 19 1 10 0 1 2
Blood Pressure Traits
Systolic Blood Pressure 74,064 31,516 29,378 - 35,433 74 2 0 4 0 1 1
Diastolic Blood Pressure 74,064 31,516 29,378 - 35,433 81 2 0 4 0 0 0
Hypertension 74,064 31,516 29,378 - 49,158 111 0 0 2 0 1 1
Anthropometric Traits
Waist-to-hip Ratio3 142,762 39,869 19,744 3,484 33,904 94 5 0 6 0 1 0
Height 253,288 36,227 20,427 - 49,781 698 99 42 93 18 5 13
Body Mass Index 236,781 82,438 39,144 3,484 49,335 572 41 12 13 0 1 0
Kidney Traits
eGFR by CKD Epi Equation 133,413 23,536 16,840 16,325 27,900 135 1 0 5 0 3 0
Average 90,953 20,953 14,710 5,570 Total 3356 548 194 333 24 27 38

For more information, see Supplementary Table 6.

1

Data only include studies indexed in the GWAS Catalog on 31 December 2016.

2

Data are shown as cases/controls.

3

Data include pooled and sex-stratified studies and/or results.

4

P < 8.71 × 10−5 for genotype:PC interactions in PAGE, adjusting for multiple tests (0.05/574).

5

P < 1.50 × 10−4 for genotype:PC interactions in PAGE, adjusting for multiple tests (0.05/333).

6

Significant loci have P < 5 × 10−8 after conditioning on all known loci from the literature.