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. Author manuscript; available in PMC: 2019 Oct 9.
Published in final edited form as: ACS Chem Neurosci. 2019 Aug 20;10(9):4160–4182. doi: 10.1021/acschemneuro.9b00410

Scheme 2. Synthesis of the First and Second Iterations of Compounds for Exploring the LHS Heterocyclic Moietya.

Scheme 2.

aReagents and conditions: (a) Pd(PPh3)4, K2CO3, dioxane, H2O, 120 °C, 25 min; (b) Cs2CO3, DMSO, 125 °C, 48 h; (c) Pd(dppf)Cl2, KOAc, B2(pin)2, dioxane, 80 °C, 18 h.