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. Author manuscript; available in PMC: 2019 Oct 9.
Published in final edited form as: ACS Chem Neurosci. 2019 Aug 20;10(9):4160–4182. doi: 10.1021/acschemneuro.9b00410

Figure 2.

Figure 2.

First iteration of analogues (2–5) derived from compound 1 to explore the effects of nitrogen methylation and addition of a carbonyl oxygen and an additional nitrogen into the RHS heterocycle. Full concentration–response curves for the first iteration of RHS analogues measured using the GloSensor assay for GS pathway activation (A) and the BRET assay for β-arrestin2 recruitment (B) as a percentage of the maximal dopamine (DA) response. Curves represent at least three independent experiments performed in triplicate. Data points represent the mean ± SEM.