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. Author manuscript; available in PMC: 2019 Oct 9.
Published in final edited form as: ACS Chem Neurosci. 2019 Aug 20;10(9):4160–4182. doi: 10.1021/acschemneuro.9b00410

Table 1.

Radioligand Binding Affinities of Compounds 10, 18, 35, 36, 37, and 40 at Select GPCRs, Ion Channels, and Transportersa

binding affinity Ki (nM)
receptor 10 18 35 36 37 40
D1 5.7 10 70 93 14 5.1
D2 NC NC NC NC NC NC
D3 NC NC NC NC NC NC
D4 NC NC NC NC NC NC
D5 6.7 15 171 185 90 53
5-HT1A NC NC NC NC NC NC
5-HT1B NC NC NC NC NC NC
5-HT1D NC NC NC NC NC NC
5-HT1E NC NC NC NC NC NC
5-HT2A NC NC NC NC NC NC
5-HT2B NC NC NC NC NC NC
5-HT3 NC NC NC NC NC NC
5-HT4 NC NC NC NC NC NC
5-HT5A NC NC NC NC NC NC
5-HT6 NC NC NC NC NC NC
5-HT7A NC NC NC NC NC NC
Alpha1A NC NC NC NC NC NC
Alpha1B NC NC NC NC NC NC
Alpha2A NC NC 6900 NC NC NC
Beta1 NC NC NC NC NC NC
Beta2 NC NC NC NC NC NC
MOR NC NC NC NC NC NC
KOR NC NC NC NC NC NC
M1 NC NC NC NC NC NC
M2 NC 7700 6900 NC NC NC
M3 NC NC NC NC 4200 4600
Sigma1 NC NC NC NC NC NC
H1 NC NC NC NC NC NC
H2 NC NC NC NC NC NC
DAT NC NC NC NC NC NC
SERT NC NC NC NC NC NC
a

Ki values represent the average of at least three triplicate experiments. SEM < ±20%. NC: Not calculated because minimum affinity threshold was not reached in primary binding assay.