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Cells sense biophysical properties of extracellular HA (adhesivity, mechanical properties, and degradability) through surface receptors such as CD44 and RHAMM. These biophysical properties influence cell adhesion, migration, and proliferation through cytoskeletal interactions, transcription, and receptor crosstalk. In turn, cells remodel extracellular HA through synthesis by hyaluronan synthases and degradation by hyaluronidases.
