Table 2:
Zebrafish models of hematological disorders
| Human Disease condition | Zebrafish transgenic line or mutant | Affected gene | Reference | ||
|---|---|---|---|---|---|
| Hereditary elliptocytosis | chablis and merlot | epb41b | (164) | ||
| Hereditary spherocytosis type 2 | riesling | b-spectrin | (167) | ||
| Hereditary spherocytosis type 4 | retsina | slc4a1 | (168) | ||
| Erythropoietic protoporphyria and X-linked sideroblastic anemia | sauternes | alas2 | (187) | ||
| hypochromic microcytic anemia | zinfandel | hbbe1.1 | (62) | ||
| hypochromic microcytic anemia | chianti | tfr1a | (188) | ||
| Hemochromatosis type 4 | weissherbst | slc40a1 | (189) | ||
| Erythropoietic protoporphyria | dracula | fech | (172) | ||
| Diamond-Blackfan anemia | rpl11 | rpl11 | (190) | ||
| Acute Myeloid leukemia | Tg(hsp:AML1-ETO) | runx1 | (175) | ||
| Acute Myeloid leukemia | Tg(spi1:lox-EGFP-lox-NUP98-HOXA9) | hoxa9 | (176) | ||
| Myelodysplastic Syndrome | Tet2 mutants | Tet2 | (191) | ||
| Myelodysplastic Syndrome | crimsonless | hspa9b | (192) | ||
| T- cell Acute lymphoblastic leukemia | Tg(rag2:EGFP-myc) | Myc-oncogene overexpression | (125) | ||
| T- cell Acute lymphoblastic leukemia | Tg(rag2:NOTCH1ICD-EGFP) | Notch1-intracellular domain overexpression | (178) | ||
| Pre-B cell Acute Lymphoblastic leukemia | Tg(ef1alpha:EGFP-TEL-AML1) | runx1 | (193) |