Table 1.

List of the adverse outcomes (AOs) and molecular initiative and key events (MIEs and KEs) associated with bisphenol S (BPS).

Name	Score (pS or wS)a	AOP-Wiki ID
AO name
Adipogenesis	0.96	16
Cancer	0.47	11
Hepatic steatosis	0.28	17
Steatosis	0.95	18
MIE/KE name
Activated LXR	3	1,421
Activation androgen receptor	1.6	785
Activation estrogen receptor	4	1,181
Activation estrogen receptor alpha	$-1$	1,065
Activation glucocorticoid receptor	2	122
Activation hepatic nuclear receptor(s)	$-2$	1,157
Activation LXR	3	167
Activation oxidative stress pathway	$-2.25$	1,238
Allergic contact dermatitis challenge	$-0.75$	312
Alteration lipid metabolism	2.66	1,060
Altered gene expression	1.66	1,239
Apoptosis	1	1,262
Binding antagonist NMDA receptors	$-1.5$	201
Breast cancer	1	1,193
Chronic high-fat diet	$-0.75$	1,454
Decrease fertility	2	330
Decrease thyroid hormone synthesis	$-0.75$	277
Decreased androgen receptor activity	$-1.25$	742
Decreased body length	1.66	315
Decreased body weight	1.66	864
Decreased testosterone	1	808
Depletion of GSH	1	130
Estrogen receptor activation	4	1,180
Glucocorticoid receptor agonist activation	$-1.5$	494
Hippocampal gene expression altered	$-1.25$	756
Impaired development	1	577
Increase DNA damage	1	1,194
Increase lipid peroxidation	2.3	1,445
Increase plasma vitellogenin concentrations	$-1.25$	220
Increase reactive oxygen species production	$-1$	257
Increased DNA damage repair	$-0.75$	1,281
Increased lethality	8.5	342
Increased neuronal synaptic inhibition	$-4$	1,015
Increased reactive oxygen species	$-0.75$	1,115
Increased triglyceride	2	881
Liver fibrosis	5.5	344
Increased glucocorticoid receptor activity	$-1.5$	1,396
Necrosis	1	1,263
Obesity	1	1,447
Oxidative stress	1	210
Production reactive oxygen species	$-0.75$	249
Reduction testosterone level	2.3	446
ROS formation	1	1,278
Skewed sex ratio	1	417

Note: GSH, glutathione; LXR, liver X receptor; NMDA, N-methyl-d-aspartate; ROS, reactive oxygen species.

^aThe position score (pS) reflects the position of the AO term in the abstract. The weighted score (wS) allows the user to quantify the extent to which a MIE/KE expression is retrieved in an abstract.