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. 2019 Oct 9;5(10):eaax7031. doi: 10.1126/sciadv.aax7031

Fig. 2. Nicotine withdrawal induces anxiety-like phenotype in mice.

Fig. 2

(A) MB test: Bar graph showing the mean value of marbles buried by Sal, Nic, and WD mice. (B) OF test: Bar chart showing the time spent in the center of the OF arena by Sal, Nic, and WD mice. (C) Locomotor activity: Bar chart showing the average distance moved in the OF arena by Sal, Nic, and WD mice. (D) Representative OF traces of Sal, Nic, and WD mice. [Compared to Sal—**q < 0.01; compared to Nic—##q < 0.01; (A to C) n = 9 to 23 per treatment group.]