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. 2019 Oct 9;5(10):eaax7031. doi: 10.1126/sciadv.aax7031

Fig. 6. Microglia depletion attenuates nicotine withdrawal–related anxiety.

Fig. 6

(A) Bar graph showing qPCR analysis of Nox2 in the nucleus accumbens of control chow and PLX5622 chow Sal, as well as their WD equivalents. (B) (i) Representative immunoblot showing the expression of carbonylated proteins in the nucleus accumbens of control chow and PLX5622 chow Sal, as well as their WD equivalents. (ii) Quantitation of (B, i). (C) MB test: Bar graph showing the mean amount of marbles buried by control chow and PLX5622 chow Sal, as well as their WD equivalents. (D) OF test: Bar chart showing the time spent in the center of the OF arena by control chow and PLX5622 chow Sal, as well as their WD equivalents. (E) Locomotor activity: Bar chart showing the average distance moved in the OF arena by control chow and PLX5622 chow Sal, as well as their WD equivalents. (F) Representative OF traces of control chow and PLX5622 chow Sal, as well as their WD equivalents. [Compared to Sal control—*P < 0.05, **P < 0.01; compared to Sal PLX5622—##P < 0.01, ###P < 0.001; compared to WD control—$P < 0.05, $$$P < 0.001; (A, Bii, C, D, and E) n = 9 to 10 per treatment group.]