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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Transfusion. 2019 Aug 12;59(10):3243–3252. doi: 10.1111/trf.15482

Figure 1. Influenza infection promotes the generation of clinically significant alloantibodies against K1 RBCs.

Figure 1.

(A) Wild type C57BL/6 mice were intranasally infected with 1 PFU (solid line) or 10 PFU (dashed line) of PR8 influenza virus, and weight was monitored daily for up to 3 weeks. (B) 3 days after influenza infection, the infected mice and naïve mice were intravenously transfused with K1 RBCs; anti-KEL glycoprotein IgG responses were measured at indicated time points post-transfusion by flow cytometric crossmatch. (C) 28 days after the initial K1 RBC transfusion, mice were re-transfused with labeled RBCs and K1 RBC post-transfusion recovery and survival of K1 RBCs was evaluated. Data are representative of 2–3 independent experiments, *p<0.05.