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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Transfusion. 2019 Aug 12;59(10):3243–3252. doi: 10.1111/trf.15482

Figure 4. Type I IFN receptor blockade prevents influenza-induced alloimmune responses to transfused K1 RBCs.

Figure 4.

(A) Wild type C57BL/6 mice were treated with IFNAR1 blocking antibody (MAR1–5A3) or an isotype matched IgG1 control 24 hours prior to influenza infection, 24 hours prior to K1 RBC transfusion, and 3 days after K1 RBC transfusion and anti-KEL IgG antibodies were evaluated by flow cytometry post-transfusion. (B) 28 days after the initial K1 RBC transfusion, these same mice were re-transfused with labeled RBCs K1 RBC post-transfusion recovery and survival was evaluated. Data shown are representative of 2 independent experiments, *p<0.05.