Table 3.
Patient characteristics, oncologic factors, procedural details, and postoperative outcomes in patients with on-time compared to delayed/omitted delivery of adjuvant chemotherapy
| On-time Chemotherapy n = 141 |
Delayed/Omitted Chemotherapy n = 222 |
p value |
|
|---|---|---|---|
| Patient characteristics | |||
| Age (years) | 59.1 (51.2-66.2) | 63.9 (55.4-73.5) | <0.001 |
| BMI (kg/m2) | 28.3 (24.0-32.2) | 28.1 (24.1-32.3) | 0.761 |
| Male | 78 (55.3%) | 125 (56.3%) | 0.854 |
| Race | 0.296 | ||
| White | 126 (89.4%) | 185 (83.3%) | |
| Black | 11 (7.8%) | 32 (14.4%) | |
| Asian | 1 (0.7%) | 1 (0.5%) | |
| Not reported | 3 (2.1%) | 4 (1.8%) | |
| Hypertension | 62 (44.0%) | 130 (58.6%) | 0.007 |
| Diabetes mellitus | 23 (16.3%) | 47 (21.2%) | 0.253 |
| ESRD | 0 (0.0%) | 2 (0.9%) | 0.258 |
| COPD | 9 (6.4%) | 9 (4.1%) | 0.319 |
| Dyspnea | 17 (12.1%) | 28 (12.6%) | 0.876 |
| Ascites | 1 (0.7%) | 4 (1.8%) | 0.384 |
| Bleeding disorder | 1 (0.7%) | 5 (2.3%) | 0.261 |
| Current smoker | 25 (17.7%) | 43 (19.4%) | 0.700 |
| 10% body weight loss | 14 (9.9%) | 20 (9.0%) | 0.769 |
| Preoperative transfusion | 1 (0.7%) | 2 (0.9%) | 0.844 |
| Chronic steroid use | 5 (3.6%) | 5 (2.3%) | 0.463 |
| Functional health status | 0.218 | ||
| Independent | 140 (99.3%) | 214 (96.4%) | |
| Partially independent | 1 (0.7%) | 7 (3.2%) | |
| Totally dependent | 0 (0.0%) | 1 (0.5%) | |
| ASA classification | 0.007 | ||
| ASA 1 | 1 (0.7%) | 0 (0.0%) | |
| ASA 2 | 73 (51.8%) | 78 (35.1%) | |
| ASA 3 | 64 (45.4%) | 134 (60.4%) | |
| ASA 4 | 3 (2.1%) | 10 (4.5%) | |
| Oncologic factors | |||
| Colon cancer | 62 (44.0%) | 86 (38.7%) | 0.323 |
| Neoadjuvant chemoradiation | 71 (50.4%) | 128 (57.7%) | 0.173 |
| Neoadjuvant chemotherapy | 14 (9.9%) | 12 (5.4%) | 0.103 |
| High grade | 49 (34.8%) | 67 (30.2%) | 0.363 |
| Final stage | 0.001 | ||
| 2 | 32 (22.7%) | 81 (36.5%) | |
| 3 | 74 (52.5%) | 114 (51.4%) | |
| 4 | 35 (24.8%) | 27 (12.2%) | |
| Procedural details | |||
| ERP | 86 (61.0%) | 103 (46.4%) | 0.007 |
| Laparoscopic/Robotic | 45 (31.9%) | 44 (19.8%) | 0.009 |
| Wound classification | 0.206 | ||
| Clean | 3 (2.1%) | 1 (0.5%) | |
| Clean/contaminated | 123 (33.9%) | 207 (93.2%) | |
| Contaminated | 13 (9.2%) | 12 (5.4%) | |
| Dirty/infected | 2 (1.4%) | 2 (0.9%) | |
| Ileostomy | 63 (44.5%) | 82 (36.9%) | 0.142 |
| Procedure duration (minutes) | 236.0 (179.0-304.0) | 241.0 (187.0-326.0) | 0.600 |
| Postoperative Outcomes | |||
| Unplanned intubation | 0 (0.0%) | 8 (3.6%) | 0.023 |
| Superficial incision SSI | 5 (3.6%) | 22 (9.9%) | 0.024 |
| Deep incisional SSI | 0 (0.0%) | 5 (2.3%) | 0.073 |
| Organ space SSI | 2 (1.4%) | 22 (9.9%) | 0.002 |
| Composite SSI | 7 (5.0%) | 46 (20.7%) | <0.001 |
| Wound disruption | 0 (0.0%) | 4 (1.8%) | 0.109 |
| UTI | 1 (0.7%) | 8 (3.6%) | 0.084 |
| Sepsis | 1 (0.7%) | 8 (3.6%) | 0.084 |
| Intraoperative/postoperative transfusion | 14 (9.9%) | 32 (14.4%) | 0.211 |
| Progressive renal insufficiency | 1 (0.7%) | 9 (4.1%) | 0.058 |
| Acute renal failure | 1 (0.7%) | 3 (1.4%) | 0.568 |
| Myocardial infarction | 0 (0.0%) | 5 (2.3%) | 0.073 |
| Cerebrovascular accident | 0 (0.0%) | 3 (1.4%) | 0.166 |
| Vein thrombosis requiring therapy | 1 (0.7%) | 5 (2.3%) | 0.261 |
| Pulmonary embolism | 0 (0.0%) | 2 (0.9%) | 0.258 |
| Complication(s) | 23 (16.3%) | 90 (40.5%) | <0.001 |
| Return to OR | 3 (2.1%) | 16 (7.2%) | 0.034 |
| Length of stay (days) | 5.0 (3.0-6.0) | 6.0 (4.0-10.0) | <0.001 |
| 30-day readmissions | 12 (8.5%) | 47 (21.2%) | 0.001 |
Categorical variables listed as N (%) and continuous variables listed as median (interquartile range)
BMI=Body mass index; ESRD=End stage renal disease; COPD=Chronic obstructive pulmonary disease; ASA Classification=American Society of Anesthesiologists physical status classification; ERP=Enhanced recovery protocol, SSI=Surgical site infection; UTI=Urinary tract infection; OR=Operating room