Table 1:

Demographic and Clinical Histories

A.	Positive Personal History of Cancera
	European	Hispanic	African	Asian and Pacific Islander
	Caucasian (5243); Ashkenazi Jewish (579)	Hispanic (267)	African (128)	Asian, not specified (96); Chinese (64); Filipino (33); Indian (10); Japanese (29); Pacific Islander (3)
Cohort size	5822	267	128	235
Gender
Male	1492	33	47	38
Female	4330	234	81	197
HBOC & LS
P/LPb	251/5822 = 4.3%	17/267 = 6.4%	10/128 = 7.8%	21/235 = 8.9%*
VUSc	355/5822 = 6.1%	23/267 = 8.6%	24/128 = 18.8%**	39/235 = 16.6%**
Other cancer genes
P/LP	561/5822 = 9.6%	19/267 = 7.1%	< 5 individuals***	15/235 = 6.4%
VUS	778/5822 = 13.4%	46/267 = 17.2%	24/128 = 18.8%	56/235 = 23.8%**
Reported cancer typesd
Breast	3245 (52.2%)	193 (70.2%)	67 (50.8%)	165 (67.6%)
Colorectal	276 (4.4%)	11 (4.0%)	9 (6.8%)	19 (7.8%)
Gastric	21 (0.3%)	2 (0.7%)	2 (1.5%)	2 (0.8%)
Melanoma	892 (14.3%)	6 (2.2%)	0 (0.0%)	1 (0.4%)
Ovarian	229 (3.7%)	17 (6.2%)	4 (3.0%)	17 (7.0%)
Pancreatic	136 (2.2%)	6 (2.2%)	6 (4.5%)	8 (3.3%)
Prostate	1203 (19.3%)	25 (9.1%)	41 (31.1%)	24 (9.8%)
Uterine	218 (3.5%)	15 (5.5%)	3 (2.3%)	8 (3.3%)
Mean Age of Onset ± Standard Deviation
Breast	52.98 ± 10.90	47.57 ± 9.67	50.22 ± 10.08	49.16 ± 10.71
Colorectal	55.34 ± 13.86	51.27 ± 8.21	47.11 ± 10.88	49.74 ± 12.89
Gastric	62.24 ± 15.87	35.50 ± 0.71	35.00 ± 9.90	52.00 ± 11.31
Melanoma	46.22 ± 14.42	41.00 ± 18.12	N/A	21.00
Ovarian	50.28 ± 15.16	46.75 ± 10.42	35.50 ± 12.79	50.69 ± 19.37
Pancreatic	64.11 ± 10.70	53.17 ± 13.01	62.80 ± 6.14	58.00 ± 11.06
Prostate	61.41 ± 8.41	54.80 ± 8.49	55.20 ± 8.37	61.58 ± 9.57
Uterine	50.00 ± 14.53	41.60 ± 15.12	50.00 ± 13.00	47.63 ± 12.28
B.	Negative Personal History of Cancer
	European	Hispanic	African	Asian and Pacific Islander
	Caucasian (28538); Ashkenazi Jewish (3382)	Hispanic (1700)	African (462)	Asian, not specified (1335); Chinese (877); Filipino (180); Indian (98); Japanese (96); Pacific Islander (16)
Cohort size	31920	1700	462	2602
Gender
Male	5683	263	101	1145
Female	26237	1437	361	1457
HBOC & LS
P/LP	1196/31920 = 3.7%	59/1700 = 3.5%	14/462 = 3%	70/2602 = 2 7%****
VUS	1837/31920 = 5.8%	120/1700 = 7 l%*****	57/462 = 12.3%**	340/2602 = 13.1%**
Other cancer genes
P/LP	2410/31920 = 7.6%	86/1700 = 5.1%**	11/462 = 2.4%**	112/2602 = 4.3%**
VUS	3887/31920 = 12.2%	275/1700 = 16.2%**	100/462 = 21.6%**	636/2602 = 24.4%**

^aBreast, Colorectal, Gastric, Melanoma, Ovarian, Pancreatic, Prostate, Uterine

^bPathogenic/likely pathogenic variants

^cVariants of uncertain significance

^dSome individuals with multiple cancer types

^*p=0.001

^**p<0.001

^***p=0.019

^****p=0.006

^*****p=0.029