Table 2.
Univariate analysis of patients with anal Paget’s disease, based on diagnosis of colorectal or other anal neoplasms.
| Characteristic | No colorectal or other anal neoplasm (n=78) | Colorectal neoplasm (n=20) | Other anal neoplasm (n=10) | Colorectal or other anal neoplasm (n=30) | P-value a |
|---|---|---|---|---|---|
| Age at diagnosis of EMPD (median, IQR) | 73.0 years (64.0–82.0) | 71.5 years (63.0–77.0) | 71.0 years (63.0–82.0) | 71.5 years (63.0–77.0) | 0.29 |
| Sex | 0.42 | ||||
| Male | 40 (51.3%) | 11 (55.0%) | 7 (70.0%) | 18 (60.0%) | |
| Female | 38 (48.7%) | 9 (45.0%) | 3 (30.0%) | 12 (40.0%) | |
| Race | 0.59 | ||||
| White | 66 (84.6%) | 15 (75.0%) | 9 (90.0%) | 24 (80.0%) | |
| Black | 2 (2.6%) | 2 (10.0%) | 0 (0.0%) | 2 (6.7%) | |
| Asian, American Indian | 10 (12.8%) | 3 (15.0%) | 1 (10.0%) | 4 (13.3%) | |
| Marital status at diagnosis of EMPD | 0.20 | ||||
| Single (never married) | 7 (9.0%) | 5 (25.0%) | 1 (10.0%) | 6 (20.0%) | |
| Married or domestic partner | 45 (57.7%) | 13 (65.0%) | 6 (60.0%) | 19 (63.3%) | |
| Divorced, separated, or widowed | 19 (24.4%) | 2 (10.0%) | 1 (10.0%) | 3 (10.0%) | |
| Unknown | 7 (9.0%) | 0 (0.0%) | 2 (20.0%) | 2 (6.7%) | |
| Region of the United States b | 0.67 | ||||
| Northeast | 7 (9.0%) | 3 (15.0%) | 1 (10.0%) | 4 (13.3%) | |
| Midwest | 8 (10.3%) | 1 (5.0%) | 1 (10.0%) | 2 (6.7%) | |
| South | 10 (12.8%) | 1 (5.0%) | 1 (10.0%) | 2 (6.7%) | |
| West | 53 (68.0%) | 15 (75.0%) | 7 (70.0%) | 22 (73.3%) | |
| Year of EMPD diagnosis | 0.49 | ||||
| 1970–1989 | 7 (9.0%) | 4 (20.0%) | 1 (10.0%) | 5 (16.7%) | |
| 1990–1999 | 16 (20.5%) | 4 (20.0%) | 2 (20.0%) | 6 (20.0%) | |
| 2000–2009 | 33 (42.3%) | 9 (45.0%) | 5 (50.0%) | 14 (46.7%) | |
| 2010–2014 | 22 (28.2%) | 3 (15.0%) | 2 (20.0%) | 5 (16.7%) | |
| Surgery type for EMPD | 0.15 | ||||
| None | 20 (25.6%) | 1 (5.0%) | 1 (10.0%) | 2 (6.7%) | |
| Local tumor destruction/excision | 27 (34.6%) | 9 (45.0%) | 5 (50.0%) | 14 (46.7%) | |
| Abdominoperineal resection | 8 (10.3%) | 4 (20.0%) | 1 (10.0%) | 5 (16.7%) | |
| Surgery NOS or unknown | 23 (29.5%) | 6 (30.0%) | 3 (30.0%) | 9 (30.0%) | |
| Vital status at end of follow-up period | 0.92 | ||||
| Alive | 32 (41.0%) | 8 (40.0%) | 4 (40.0%) | 12 (40.0%) | |
| Dead | 46 (59.0%) | 12 (60.0%) | 6 (60.0%) | 18 (60.0%) | |
a
P-values are based on t-tests and Fisher Exact tests comparing patients with no colorectal or other anal neoplasm versus patients with a colorectal or other anal neoplasm.
b
Based on United States Census Bureau designations.
EMPD, extramammary Paget’s disease; IQR, interquartile range; NOS, not otherwise specified