Table 4.
Multivariable Cox proportional hazards analysis of predictors of mortality in patients with anogenital Paget’s disease.
| Variable | Hazard Ratio | 95% Confidence Interval | P-value | |
|---|---|---|---|---|
| Age at diagnosis of EMPD | ||||
| ≤ 60 years old | Reference | |||
| 61–70 years old | 2.45 | 1.84 | 3.25 | <0.001 |
| 71–80 years old | 5.28 | 4.00 | 6.98 | <0.001 |
| >80 years old | 12.78 | 9.58 | 17.05 | <0.001 |
| Sex | ||||
| Female | Reference | |||
| Male | 2.17 | 1.29 | 3.65 | 0.004 |
| Race | ||||
| White | Reference | |||
| Black | 1.15 | 0.53 | 2.51 | 0.72 |
| Asian, American Indian | 0.75 | 0.62 | 0.91 | 0.003 |
| Unknown | 0.13 | 0.02 | 0.92 | 0.04 |
| Marital status at diagnosis of EMPD | ||||
| Single (never married) | Reference | |||
| Married or domestic partner | 0.91 | 0.70 | 1.18 | 0.47 |
| Divorced, separated, or widowed | 1.14 | 0.87 | 1.49 | 0.33 |
| Unknown | 1.01 | 0.73 | 1.40 | 0.94 |
| Primary site of EMPD | ||||
| Anal | Reference | |||
| Male genital | 0.62 | 0.41 | 0.94 | 0.03 |
| Female genital | 0.39 | 0.27 | 0.56 | <0.001 |
| Diagnosis of other proximal or local neoplasm | 1.01 | 0.80 | 1.26 | 0.95 |
| Surgery type for EMPD | ||||
| None | Reference | |||
| Local tumor destruction/excision | 0.71 | 0.55 | 0.92 | 0.01 |
| Partial removal of primary site | 0.68 | 0.53 | 0.87 | 0.002 |
| Total removal of primary site, or debulking, or radical surgery | 1.01 | 0.76 | 1.33 | 0.96 |
| Surgery NOS or unknown | 1.02 | 0.82 | 1.28 | 0.86 |
EMPD, extramammary Paget’s disease; NOS, not otherwise specified