Fig. 2. The levels of serum αSyn and Rab35 are increased in PD mice models. Compared with control mice, the serum levels of αSyn and Rab35 were up-regulated in mice treated with MPTP for either 1 or 2 weeks (A and B). Scatter plot of natural-logarithm values of the serum αSyn and Rab35 levels. The fitted regression line shows that there was a positive correlation between these levels in MPTP-treated mice (r=0.671, p=0.0011) (C). The levels of serum αSyn and Rab35 were increased in 6M and 9M (D331Y) PLA2G6 knockin mice compared to 6M and 9M wild-type mice (D and E). Scatter plot with a fitted regression line demonstrating a positive correlation between these levels in (D331Y) PLA2G6 knockin mice (r=0.7438, p=0.0271) (F). ^*p<0.05, ^†p<0.01 compared with NC. 6M: six-month-old, 9M: nine-month-old, αSyn: alpha-synuclein, Ln: natural logarithm, MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, NC: normal controls, PD: Parkinson's disease, WT: wild-type.