Figure 2.

In vitro release of iodixanol from IX-lipo. (A) Left: illustration of the release experiment in which the IX-lipo containing dialysis bag is immersed in PBS. The dialysate is measured at 246 nm (UV) intermittently to monitor iodixanol release. Right: representative release profile. (B) Concentration of iodixanol retained in liposomes measured by CT and CEST MRI as compared to the concentration released as measured by the UV absorbance in the solution and back-calculated to the concentration inside liposomes using a volume ratio of 100:2. (C) Time dependence of iodixanol release obtained from all three methods. CEST MRI, chemical exchange saturation transfer magnetic resonance imaging.