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Calibration curves for the CEST signal of iodixanol in solution using (A) MTRasym and (B) MTRrex. For the MTRasym, as it is only linear when the concentration is low (i.e., <10 mM), we used a non-linear Michaelis-Menten curve fitting. The MTRrex was calculated from the reciprocal format of Z-spectrum by MTRrex (∆ω) = S0 / Ssat (+∆ω) – S0 /Ssat (–∆ω). A good linearity was found between the MTRrex signal at 4.3 ppm and iodixanol concentrations (Y=0.0316X, R2=0.9994).
