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. 2019 Oct 9;9:14476. doi: 10.1038/s41598-019-50891-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mutation profiles of LTTs. Mutational spectra of (a) RT-112-LTT, (b) J82-LTT, (c) 253J-LTT, and (d) T-24-LTT relative to their parental UCCs are displayed according to the 96 substitution classification defined by the substitution class and sequence context of the mutated base by Alexandrov et al. (2014). Note that the number of mutations in J82-LTT is too low to allow the generation of a representative profile. (e) Common variants found in RT-112-LTT, J82-LTT, 253J-LTT, and T-24-LTT for all variants (left Venn diagram) and exonic nonsynonymous variants (right Venn diagram).