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. 2019 Oct 9;9:14482. doi: 10.1038/s41598-019-50848-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extracellular vesicles (EVs) shedding by murine melanoma cells after TMZ treatment induces macrophage polarization towards M2 phenotype. qRT-PCR for analyzing the expression level of typical M1 (iNOS and IL12p40) (a) and M2 (MRC1, Arg1 and IL10) (b) genes in F4/80⁺ macrophages in the presence of EVs from control- and TMZ-treated cells. HPRT was used as housekeeping gene. EVs from control cells were used as the reference and EVs from TMZ-treated cells as the target sample. Bars indicate mean ± SD of five independent experiments. Results were considered significant when p < 0.05 by Mann-Whitney test.