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. 2019 Oct 9;9:14473. doi: 10.1038/s41598-019-50483-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Unlike the DMN’s functional connectivity, its negative BOLD response correlates with performance during a 2-back working memory task. Subject-wise median response time correlates with the subject-wise magnitude of the NBR in the DMN regions during a 2-back working memory task (β = 83.16, p < 0.0002). However, it does not correlate with the subject-wise expression of functional connectivity in DMN regions during the same tb-fMRI scan (β = 5.73, p > 0.14), providing evidence for differential level of involvement of the two fMRI measurements in task execution. Each dot represents a single subject and the line presents the linear fit to the data.