Fig. 1.

a Leave-one-out cross-validation process. Example of leave-one-out cross-validation process for a sample containing four datasets. The same process was followed with the 39 PGC datasets. b Flowchart for polygenic score generation in each leave-one-out Iteration. Flowchart of the process followed in each iteration of the leave-one-out cross-validation. PRS input files are the polygenic scoring file and the individual SNP p-value file. PRS polygenic risk score; LRT likelihood ratio test