Fig. 3.

MPH actions outside the dmPFC. Infusion of MPH into the vmPFC (a), dmSTR (b), or vmSTR (c) had no effect on sustained attention as measured by change in d′ compared with vehicle treatment (mean ± SEM). A trend for improvement was seen with the highest dose (2.0 µg) of MPH infused into the vmPFC (ventral prelimbic/infralimbic PFC), which likely reflects diffusion into the dmPFC at a lower concentration. Schematics depict all MPH infusion sites for each region. Numbers represent anterior/posterior coordinates of coronal sections. Photomicrographs depict representative infusion sites for each region. Arrows indicate ventral most extent of infusion needles. PL prelimbic PFC, IL infralimbic PFC, CP caudate putamen, CC corpus callosum, Acb nucleus accumbens, LV lateral ventricle