Table 1.

Muscimol (75 ng/hemisphere) inactivation within frontostriatal nodes

Region	d′	Prop correct	Pr(hit)	Pr(FA)	No responses
dmPFC	1.07 ± 0.20**	0.18 ± 0.04**	−0.24 ± 0.06**	0.12 ± 0.05*	−1.07 ± 3.39
dmSTR	0.88 ± 0.28*	−0.12 ± 0.05	−0.18 ± 0.08**	0.11 ± 0.07	1.14 ± 4.96
vmSTR	1.99 ± 0.26**	0.55 ± 0.05**	−0.30 ± 0.07**	0.32 ± 0.06**	44.19 ± 4.64**

The GABA-A agonist, Muscimol (75 ng/hemisphere), was used to inactivate three nodes in the frontostriatal network prior to testing in the sustained attention task. Infusion into the dmPFC and dmSTR reduced sustained attention performance to near chance. In contrast, vmSTR inactivation produced a more profound impairment, driven by animals no longer performing the task following a series of errors. Data presented are expressed as a change from vehicle *p < 0.05, **p < 0.01 compared to vehicle treatment