Figure 2. Effect of hesperidin on alterations induced by BLM in lung Nrf2, HO-1, TNF-α, IL-1β and IL-6 mRNA expression of rats (A) on day 14, quantitative representation of mRNA expression of Nrf2 (B), HO-1 (C), TNF-α (D), IL-1β (E) and IL-6 (F). Data were analyzed by One-Way ANOVA, followed by Tukey's multiple range post-tests. p < 0.05 when compared with: sham group (&), normal group (#), each other (MP or hesperidin) group ($), and BLM control group (*). BLM: Bleomycin, MP: Methylprednisolone, HO-1: Heme oxygenase 1, ILs: interleukin, Nrf2: nuclear factor E2-related factor 2, TNF-α: tumor necrosis factor-alpha. (n=4).