Figure 4. Effect of hesperidin on alterations induced by BLM in lung NF-κB (A), IκBα (B), AMPK (Thr-172) (C) and PP2C-α (D) protein expression of rats on day 28. Data were analyzed by One-Way ANOVA, followed by Tukey's multiple range posttests. p < 0.05 when compared with: sham group (&), normal group (#), each other (MP or hesperidin) group ($), and BLM control group (*). BLM: Bleomycin, NF-κB, nuclear factor-kappa B; IκBα: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha; Thr-172: Threonine-172 within the catalytic subunit (alpha) of AMPK; PP2C-α: Protein phosphatase 2C-Alpha; GAPDH: Glyceraldehyde 3-phosphate dehydrogenase. (n=4).
