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. 2019 Oct;60(10):1474–1482. doi: 10.2967/jnumed.119.226423

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© 2019 by the Society of Nuclear Medicine and Molecular Imaging.

Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

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FIGURE 6. — In vivo evaluation of ¹¹¹In-PA-L1 and ¹¹¹In-PA-WT^K563C in MDA-MB-231 tumor-bearing SCID mice. (A) Blood clearance of ¹¹¹In-PA-L1 and ¹¹¹In-PA-WT^K563C. (B) Ex vivo biodistribution showing uptake of ¹¹¹In-PA-L1 or ¹¹¹In-PA-WT^K563C in selected tissues and blood, 3 h after intravenous administration. (C) Tumor-to-blood ratios determined from B. (D and E) Representative coronal and sagittal maximum-intensity projections of SPECT/CT images, 3 h after administration of ¹¹¹In-PA-L1 or ¹¹¹In-PA-WT^K563C. *P < 0.05. **** P < 0.0001. b = bladder; h = heart; k = kidneys; l = liver; t = tumor.