. 2019 Sep 2;15(10):5727–5736. doi: 10.1021/acs.jctc.9b00548

Table 2. Computational Cost of Each Technique as Applied Here^a.

technique	system applied to here	required simulation time (μs)
PMF	Kir2.2, AAC, LeuT	50–75
FEP	Kir2.2, AAC, LeuT	25–40
ABFE	A_2AR	35
WTMetaD	Kir2.2, AAC, LeuT, A_2AR	120–190

Reporting the simulation time used in each of the analysis measures here. Note that, as described in the Discussion, these values may overestimate the time required for convergence.

Table 2. Computational Cost of Each Technique as Applied Herea.

Table 2. Computational Cost of Each Technique as Applied Here^a.