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. 2019 Oct 10;17:339. doi: 10.1186/s12967-019-2087-9

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Mutant genes vary during platinum treatment. a Landscape of mutant genes during platinum-based chemotherapy. The y-axis represented the gene frequency post chemotherapy, whereas the x-axis represented the gene frequency pre chemotherapy. Each grey dot on behalf of one gene. Gene name with different color denoted its category. Light green line referred x-value equal to y-value. And the yellow lines showed the mean value of gene frequency. Plasma VAFs of common reporter during platinum-based chemotherapy were shown in b and c