Fig. 5.

Activation of lysine degradation pathway impairs cancer cell proliferation. (a) KEGG pathways enriched in model-predicted proliferation-suppressing targets. (b) Monotonousness scores for model-predicted proliferation-suppressing enzymes. Enzymes selected for experimental validation are highlighted in red. (c) Relative numbers of cells after 4 days upon AADAT over-expression in the tested cell lines. OE: over-expression. P-values were computed using Wilcoxon’s rank sum test. P-value< 0.05 was considered as significant. (d) Relative numbers of cells after 4 days upon AASS over-expression in the tested cell lines. P-values were computed using Wilcoxon’s rank sum test. P-value< 0.05 was considered as significant