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. 2019 Oct 10;17:124. doi: 10.1186/s12964-019-0439-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Over-expression of metabolic enzymes inhibits the Warburg effect. (a) KEGG pathways enriched in model-predicted Warburg effect-suppressing targets. (b) Monotonousness scores for model-predicted Warburg effect-suppressing enzymes. Enzymes selected for experimental validation are highlighted in red. (c-g) Relative values of ECAR/OCR ratio after 4 days upon (c) MDH2; (d) CTPS1; (e) CTPS2; (f) PYCR1; (g) PYCR2 over-expression in the tested cell lines. P-values were computed using Wilcoxon’s rank sum test. P-value< 0.05 was considered as significant