Fig. 8.

Schematic illustration for the role of the signaling through Fyn PTK in myelination. The signal from neuron–oligodendrocyte interaction (such as from L-MAG) activates Fyn PTK. Fyn phosphorylates its substrates and stimulates transcription factors. Thus, MBP gene transcription is stimulated and the amount of MBP increases, which is necessary for forming myelin. The Fyn response element and the positions of the interferon-γ response element core sequence (γ-IRE CS) and NF-IL6 core sequence (NF-IL6 CS) are indicated with their consensus sequences. Single letter code: W = Aor T, K = G orT, Y = C orT, N = A orG or C or T.