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. 1999 Feb 15;19(4):1359–1370. doi: 10.1523/JNEUROSCI.19-04-01359.1999

Fig. 2.

Fig. 2.

A, Quantification of TH-positive cells in cocultures of dissociated OB neurons plus OE explants and dissociated OB cells plus respiratory epithelium explants. The ordinate shows the percentage of control TH neuron numbers, and the abscissa shows culture conditions. When olfactory bulb neurons are cultured with olfactory epithelial explants, the number of TH-positive OB neurons rises to 240% of control numbers. (p < 0.00001 vs OB cells alone). Cocultures with respiratory epithelium show no significant induction of TH-positive neurons. B, Cocultures of OB neurons containing fewer OE explants thanA induce 160% of control TH neuron numbers. This was enhanced to 265% of control after pulses of odorant (*p < 0.01 vs unstimulated OB–OE cocultures).