Skip to main content
. 1999 Feb 15;19(4):1359–1370. doi: 10.1523/JNEUROSCI.19-04-01359.1999

Fig. 3.

Fig. 3.

Quantification of TH-positive cells in cocultures of dissociated OB neurons plus OE explants (A) treated with either 1 mm kyurenic acid, 50 μmAPV, or 10 μm DNQX (B). The addition of either 1 mm kyurenic acid or 50 μm APV prevented the induction of TH neurons in cocultures (*p < 0.001 vs OB–OE coculture) and significantly reduced the basal TH neuron numbers (p < 0.01 for kyurenic acid). In the presence of DNQX, TH neurons show a reduced level of induction in cocultures (*p < 0.01 vs OB–OE cocultures) without affecting basal levels. B, OB neurons alone stimulated with vehicle pulses show baseline TH expression. This expression is enhanced by the addition of OE explants (p < 0.001) and further enhanced by odorant stimulation (p < 0.01). Odorant stimulation of OB neurons in the absence of OE explants did not significantly affect TH expression (Fig. 2B). The addition of 100 μm APV prevented all TH induction by OE explants and odor stimulation (*p < 0.01 vs odorant-stimulated OB–OE cocultures).