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The X11 protein family participates in multiple protein complexes in neurons. Schematic representation of the different proteins interacting with X11 proteins. X11α and X11β are highly expressed in brain, whereas X11γ is ubiquitously expressed. APP binds to all three X11 PTB domains, whereas the mLin-2/CASK–mLin-7 complex only interacts with X11α. The Munc-18-1–Syntaxin neuronal complex interacts with the neuronal X11 species. Neurexins and syndecans binds to the mLin-2/CASK PDZ domain.
