Fig. 6.

Effects of DA-induced variations in a dendritic “HVA Ca²⁺ channel.” All other network parameters had the baseline values given in Table 1. OVL, Overlap;CON, connectivity. A, Decreasing the coupling strength (λ_pd) between the proximal and the distal “pyramidal cell” compartment diminishes the impact of intervening patterns on current network activity (as measured byI_aff,crit). This tendency is much more pronounced for short stimulus presentation times (Δt_stim). OVL = 15%;CON = 25%. Dashed vertical lines indicate the parameter range within which λ_pd during full network simulations varied. B, Reduction of the amplitude (I_HVA,max) of an explicitly modeled dendritic HVA Ca²⁺ channel has a stabilizing effect within a reasonable parameter range (I_HVA,max < 0.17) at different overlaps (CON = 25%). C, Reduction of the amplitude (I_HVA,max) of an explicitly modeled dendritic HVA Ca²⁺ channel has a stabilizing effect within a reasonable parameter range at different connectivities (OVL = 15%).