Table 1. Clinicopathologic Characteristics stratified by time from biopsy to surgery.
| Overall Cohort† (N=7350) | ≤ 3 weeks (N=971 (%)) | 4-6 weeks (N=1179) (%) | 7-12 weeks (N=3375) (%) | 12-26 weeks (N=1615) (%) | >26 weeks (N=210) (%) | p-value | ||
|---|---|---|---|---|---|---|---|---|
| Mean age at surgery (SD) | 61.5±7.1 | 63.3±7.3 | 62.7±7.1 | 60.8±7.1 | 61.0±6.8 | 62.3±6.3 | <0.001* | |
| Mean BMI at surgery (kg/cm2) (SD) | 28.1±4.0 | 28.3±3.9 | 28.6±4.0 | 27.9±3.9 | 28.3±4.1 | 28.3±4.0 | <0.001* | |
| Mean preoperative PSA (ng/mL) (SD) | 7.1±7.3 | 8.6±11.7 | 8.3±9.0 | 6.7±5.9 | 6.1±4.6 | 6.5±5.0 | <0.001* | |
| Clinical stage (%) | <0.001 | |||||||
| cT1 | 4380 (60.2) | 428 (44.5) | 564 (48.4) | 2128 (63.6) | 1107 (69.5) | 153 (74.3) | ||
| cT2 | 2778 (38.2) | 513 (53.3) | 558 (47.9) | 1179 (35.2) | 477 (30.0) | 51 (24.8) | ||
| cT3 | 115 (1.6) | 21 (2.2) | 44 (3.8) | 40 (1.2) | 8 (0.5) | 2 (1.0) | ||
| Biopsy Gleason score (%) | <0.001 | |||||||
| ≤6 | 5035 (69.0) | 654 (68.5) | 721 (61.9) | 2276 (67.6) | 1205 (75.3) | 179 (85.2) | ||
| 7 | 1882 (25.8) | 212 (22.2) | 344 (29.5) | 936 (27.8) | 362 (22.6) | 28 (13.3) | ||
| 8-10 | 380 (5.2) | 89 (9.3) | 100 (8.6) | 154 (4.6) | 34 (2.1) | 3 (1.4) | ||
| TRUS volume (SD) | 37.9±19.9 | 38.6±20.7 | 37.5±19.9 | 37.3±19.7 | 38.6±19.7 | 41.2±19.4 | 0.01* | |
| NCCN Risk Group (%) | <0.001 | |||||||
| Low | 3936 (53.6) | 418 (43.0) | 494 (41.9) | 1838 (54.5) | 1040 (64.4) | 146 (69.5) | ||
| Intermediate | 2774 (37.7) | 404 (41.6) | 512 (43.4) | 1288 (38.2) | 514 (31.8) | 56 (26.7) | ||
| High | 640 (8.7) | 149 (15.3) | 173 (14.7) | 249 (7.4) | 61 (3.8) | 8 (3.8) | ||
| Pathological Gleason score (%) | <0.001 | |||||||
| ≤ 6 | 4249 (58.0) | 606 (62.5) | 630 (53.5) | 1914 (56.8) | 971(60.5) | 128 (61.2) | ||
| 7 | 2632 (35.9) | 268 (27.6) | 428 (36.4) | 1277 (37.9) | 584 (36.4) | 75 (35.9) | ||
| 8 – 10 | 449 (6.1) | 96 (9.9) | 119 (10.1) | 177 (5.3) | 51 (3.2) | 6 (2.9) | ||
| Surgeon | <0.001 | |||||||
| 1 | 2627 (35.7) | 193 (19.9) | 202 (17.1) | 1585 (47.0) | 575 (35.6) | 72 (34.3) | ||
| 2 | 1109 (15.1) | 329 (33.9) | 392 (33.2) | 305 (9.0) | 69 (4.3) | 14 (6.7) | ||
| 3 | 1354 (18.4) | 414 (42.6) | 433 (36.7) | 358 (10.6) | 118 (7.3) | 31 (14.8) | ||
| 4 | 1309 (17.8) | 28 (2.9) | 92 (7.8) | 594 (17.6) | 539 (33.4) | 56 (26.7) | ||
| 5 | 951 (12.9) | 7 (0.7) | 60 (5.1) | 533 (15.8) | 314 (19.4) | 37 (17.6) | ||
| Robotic (%) | 2055 (28.0) | 21 (2.2) | 107 (9.1) | 1014 (30.0) | 824 (51.0) | 89 (42.4) | <0.001 | |
| Mean Blood loss (cc) (SD) | 828.8±1867.8 | 965.8±2019.6 | 843.6±1770.2 | 845.4±1918.8 | 700.0±1708.2 | 837.1±1974.3 | 0.01* | |
| pN1 (SD) | 184 (2.5) | 38 (3.9) | 55 (4.7) | 72 (2.1) | 16 (1.0) | 3 (1.4) | <0.001 | |
| Mean time to death (years) (SD) | 8.2±4.8 | 12.0±4.7 | 10.0±4.9 | 7.6±4.4 | 5.9±3.7 | 6.4±4.7 | <0.001 | |
*
Means compared using ANOVA