Table 2.
Clinical characteristics, management and outcomes of recurrent fungal infection after therapeutic penetrating keratoplasty
| Characteristics | Results |
|---|---|
| Age (mean±standard deviation) | 42.9±11.8 years |
| Gender, male:female | 1.2:1 |
| Time interval of recurrence | |
| 1-7 days | 8 eyes (40%) |
| 8-20 days | 5 eyes (25%) |
| >20 days | 7 eyes (35%) |
| Size of donor graft | |
| 8-9 mm | 4 eyes (20%) |
| 9-11 mm | 10 eyes (50%) |
| >11 mm | 6 eyes (30%) |
| Site of initial recurrence | |
| Anterior chamber | 7 eyes (35%) |
| Graft-host junction | 5 eyes (25%) |
| Anterior chamber + graft-host junction | 5 eyes (25%) |
| Anterior chamber + posterior segment involvement | 4 eyes (20%) |
| Microbiology characteristics (Smear+/-Culture) | |
| Acremonium spp | 1 eye (5%) |
| Aspergillus flavus | 2 eyes (10%) |
| Dematiaceous fungus | 1 eye (5%) |
| Fusarium spp | 1 eye (5%) |
| Fungal filaments on smear (no growth) | 11 eyes (55%) |
| Management | |
| Medical therapy alone | 5 eyes (25%) |
| Medical therapy + anterior chamber wash | 8 eyes (40%) |
| Medical therapy + repeat ThPK | 4 eyes (20%) |
| PPV + intravitreal injection (Amphoptericin B) | 2 eyes (10%) |
| Evisceration | 3 eyes (15%) |
| Eventual outcomes | |
| Anatomical restoration | 13 eyes (65%) |
| Phthisis | 4 eyes (20%) |
| Anophthalmos | 3 eyes (15%) |