Table 3.
Characteristics | Xie et al., 2001 | Rogers et al., 2013* | Sharma et al., 2013 | Present study |
---|---|---|---|---|
Number of transplants | 108 | 32 | 506 (106/506 eyes had Fungal keratitis) | 198 |
Study period | 4 years (1996-1999) | 10 years (2001-2011) | 10 years (1999-2009) | 3 years (2008-2010) |
Country | China | USA | India | India |
Age (years) | <20: 3.7% 21-40: 48.2% 41-60: 39.8% >60: 8.3% |
Median: 59 Range: 16-86 |
Mean: 45.6 Range: 14-72 |
Mean±SD: 45±14.3 |
Male: Female | 1.8:1 | 0.9:1 | 0.7:1 | 1.9:1 |
Infiltrate size (mm) | <6: 13.9% 6.1-8: 36.1% >8: 50% |
Minimum median diameter of infiltrate 1.50 mm | Mean 8.19±2.13 | <6: 20.7% 6-8: 38.9% >8: 40.4% |
Donor tissue size (mm) | 7.25-8: 40% 8.5-9: 25.9% >9: 33.3% |
Not available | <9: 44% 9-11: 39% >11: 16.6% |
8-9 mm - 17.6% 9-11 mm - 54.5% >11 mm - 24.7% |
Organism |
Aspergillus spp: 14.4% Candida spp: 9.3% Fusarium spp: 65% Penicillium spp: 4.1% Unidentified: 7.2% |
Alternaria spp: 9.4% Aspergillus spp: 12.5% Candida spp: 28.1% Fusarium spp: 34.4% Other filamentous fungi: 12.5% Other yeasts: 3.1% |
Fungal: 20.9% (Aspergillus spp. Most common) Bacterial: 31% Mixed Bacterial and Fungal: 6.9% Acanthamoeba: 1.6% |
Aspergillus flavus: 32.3% Acremonium spp: 17.7% Fusarium spp: 15.7% Cladosporium spp: 0.5% Unidentified hyaline: 27.2% Curvularia spp: 1% Dematiaceous fungi: 5.1% Scedosporium spp: 0.5% |
Clear cornea | 79.6% at an average follow-up of 18.3 months | 53.1% at a median follow-up of 25 months | Not available | 12.3% at a follow up of 12 months, 10.6% at 24 months and 6.1% at 48 months |
Recurrence rate | 7.4% | 9.4% | Reinfection noted in 12.6% | 10.1% |
Graft failure | 13.9% at 24 months | 46.9% at 70 months | Not available | 71.7% at 60 months |
*Eyes that were treated with medical therapy and therapeutic keratoplasty were included in the comparison