. 2019 Oct 7;7:e7816. doi: 10.7717/peerj.7816

Table 3. Univariate and multivariate analyses of overall survival in patients with liver cancer.

Varible	Univariate analysis			Multivariate analysis
	HR	p value	95% CI	HR	p value	95% CI
CELSR3 expression (high/low)	1.85	0.001^*	1.296–2.629	1.88	0.004^*	1.227–2.883
Age, years (≥60/<60)	1.19	0.339	0.836–1.683
Gender (male/female)	0.80	0.218	0.562–1.141
Family history of cancer (yes/no)	1.19	0.349	0.826–1.721
Tumor status (with tumor/tumor free)	1.53	0.021^*	1.068–2.200	1.14	0.544	0.750–1.724
Radiation therapy (no/yes)	0.91	0.869	0.288–2.861
Histological type (hepatocholangio carcinoma/hepatocellular/fibrolamellar)	0.45	0.37	0.077–2.605
Histologic grade ((G4/G3/G2/G1))	1.11	0.368	0.881–1.408
Vascular invasion (Macro/Micro/None)	1.36	0.063	0.984–1.888
Stage ((IV/III/II/I))	1.67	0.000^*	1.361–2.048	1.06	0.919	0.373–2.986
T classification (TX/T4/T3/T2/T1)	1.64	0.000^*	1.380–1.939	1.43	0.481	0.525–3.918
N classification (NX/N1/N0)	1.21	0.040^*	1.009–1.459	1.01	0.933	0.763–1.342
M classification (MX0/M1/M0)	1.26	0.013^*	1.050–1.518	1.17	0.297	0.869–1.585
Residual tumor (RX/R2/R1/R0)	1.48	0.001^*	1.1791.866	1.36	0.033^*	1.026–1.799

Notes.

P < 0.05.