Table 2.
Effects of genetic variants at the FCGR2/3 locus on immune function.
| Effect on | More immune activation | Less immune activation | |
|---|---|---|---|
| FCGR2A-p.His166Arg | Affinity for IgG | His | Arg |
| FCGR3A CNV | Expression of activating receptor | CNV > 2 | CNV <2 |
| FCGR3A-p.Val176Phe | Affinity for IgG | Val | Phe |
| FCGR2C haplotype | Expression of activating receptor | Classic ORF | Stop/ Non-classic ORF |
| FCGR2B-p.Ile232Thr | Strength of inhibitory signal | Thr | Ile |
| FCGR2B promotor haplotype | Expression of inhibitory receptor | 2B.1 | 2B.4 |
| FCGR3B CNV | Expression of receptor | ? | ? |
| FCGR3B haplotype | Phagocytosis (unknown mechanism) | NA1 | NA2 |
?, no clear net result on immune activation.