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Effect of Ca1a on WT and mutant Nav1.4 expressed in HEK293T cells. a The sequence of the DIIS3-S4 linkers of Nav1.2–1.7. Amino acids of interest in the sequence are shaded in yellow. b Representative current traces for WT and mutant channels (N655D, Q657E, and N655D/Q657E) inhibited by 1 µM Ca1a. c Dose–response inhibition curves of Ca1a on WT and mutant Nav1.4 channels. Means ± SEM
