AsIV decreased CaSR expression and increased phosphorylation level of ERK1/2 in cardiomyocytes. a, b CaSR protein expression in cardiomyocytes was determined by western blot. c, d ERK1/2 and p-ERK1/2 expression was determined by western blot. Data represent the mean ± SD of three independent experiments. **P < 0.01 vs. Con group, ##P < 0.01 vs. H/R group, &P < 0.05, &&P < 0.01 vs. AsIV group