Fig. 3.

Kinetic profiles of the formation of β-oxidative and reductive metabolites in primary rat hepatocytes (a–c), the formation of β-oxidative metabolites in rat hepatic mitochondria (d–f) and reductive metabolites in rat hepatic mitochondria (NADH-dependent and NADPH-dependent) and microsomes (mic, NADPH-dependent) (g–i) from pyragrel, ozagrel and cinnamic acid. The kinetic profiles of the formation of pyragrel, ozagrel and cinnamic acid from pyragrel-M2, ozagrel-M2, and phenylpropionic acid in mitochondria (FAD⁺-dependent) (j–l). Data are expressed as the means ± SD of 3 rats