Fig. 5.

Effects of triclosan on the reduction of pyragrel (a, d and g), ozagrel (b, e and h) and cinnamic acid (c, f and i) in rat hepatic mitochondria with NADPH (a–c) or NADH (d–f), and in rat hepatic microsomes with NADPH as a cofactor (g–i). The effects of different NAD⁺/NADPH (j) and NAD⁺/NADH ratios (k) on the formation of pyragrel-M1/2 in rat hepatic mitochondria. Data are expressed as the means ± SD of 3 rats, *P < 0.05, **P < 0.01 vs control (a–i); ^$P < 0.05, ^$$P < 0.01 vs 1:4 group for pyragrel-M1, ^##P < 0.01 vs 1:4 group for pyragrel-M2 (j and k)