Fig. 6.

The observed (dots and error bars, means ± SD of 6 rats) and fitted (line) plasma concentrations of pyragrel (a), ozagrel (b) and cinnamic acid (c) and their corresponding metabolites following an intravenous administration of pyragrel (15 mg/kg), ozagrel (6 mg/kg) or cinnamic acid (2 mg/kg) to rats. d The relationship of the estimated total clearance of M1 and M2 in vivo and the predicted clearance of M1 and M2 in vitro from the organelles (open square) or hepatocytes (solid square), in which the solid and dashed lines indicate unity and two-fold errors between the fitted and observed data, respectively