Table 3.

PK parameters after treatment with 400 mg/kg IMB17–15 by gavage in hamsters (n = 6)

Parameter	Value
Ka (1/h)	2.19 ± 0.57
K10 (1/h)	0.12 ± 0.04
K12 (1/h)	0.86 ± 0.57
K21 (1/h)	0.50 ± 0.33
t1/2(α) (h)	0.78 ± 0.65
t1/2(β) (h)	17.97 ± 5.11
t1/2(Ka) (h)	0.35 ± 0.13
Cmax (μg/mL)	37.57 ± 3.39
Tmax (h)	0.87 ± 0.32
AUC0-t (μg/mL*h)	455.85 ± 82.76
MRT (h)	24.44 ± 6.07

PK parameters were generated using two-compartment model analysis, K_a absorption rate constant, K₁₀ elimination rate constant, K₁₂ and K₂₁ transfer rate constant, t_1/2(α) distribution half-life, t_1/2(β) elimination half-life, t_1/2(Ka) absorption half-life, C_max peak plasma concentration, T_max time to C_max, AUC_0-t area under the curve until the last time point, MRT mean residence time

The values are expressed as the mean ± SD (n = 6 in each group)