Table 2.
Percentage of cumulative radioactivity recovered from six healthy male volunteers after a single 402-mg oral dose of [14C]pyrotinib
| Time period | Feces | Urine (% dose) | Total | |
|---|---|---|---|---|
| 0–24 h | Mean (range) | 51.9 (33.4–71.8) | 0.8 (0.7–1.1) | 52.6 (34.1–72.9) |
| 0–48 h | Mean (range) | 81.5 (76.1–84.4) | 1.1 (0.9–1.6) | 82.6 (77.2–85.4) |
| 0–72 h | Mean (range) | 85.5 (80.5–87.3) | 1.2 (1.0–1.7) | 86.7 (81.6–89.0) |
| 0–96 h | Mean (range) | 87.9 (81.4–91.4) | 1.3 (1.1–1.8) | 89.2 (82.6–92.7) |
| 0–120 h | Mean (range) | 89.1 (82.3–92.4) | 1.4 (1.2–1.9) | 90.5 (83.5–93.9) |
| 0–144 h | Mean (range) | 89.8 (83.2–92.7) | 1.5 (1.2–2.0) | 91.3 (84.4–94.3) |
| 0–168 h | Mean (range) | 90.4 (83.4–93.2) | 1.6 (1.3–2.0) | 92 (84.7–94.9) |
| 0–192 h | Mean (range) | 90.6 (83.4–93.4) | 1.6 (1.3–2.1) | 92.2 (84.7–95.2) |
| 0–216 h | Mean (range) | 90.8 (83.8–93.6) | 1.7 (1.3–2.3) | 92.5 (85.1–95.5) |
| 0–240 h | Mean (range) | 90.9 (84.1–93.6) | 1.7 (1.3–2.3) | 92.6 (85.4–95.5) |