Table 3.
Levels of covalently bound radioactivity in plasma
| Time | Total radioactivity (plasma) | Covalent bound radioactivity (plasma pellet) |
|---|---|---|
| h | ng eq./mL | ng eq./mL (%) a |
| 0 | BLQ | – |
| 1.00 | 207 | – |
| 2.00 | 324 | 95.8 (29.3) |
| 3.00 | 351 | – |
| 4.00 | 378 | – |
| 5.00 | 368 | 122 (33.2) |
| 6.00 | 311 | – |
| 8.00 | 269 | 94.0 (34.9) |
| 12.0 | 232 | 101 (43.5) |
| 24.0 | 166 | 84.1 (50.7) |
| 48.0 | 112 | 73.0 (65.2) |
| C max | 378 | 122 (32.3) |
| t max | 4 | 5 |
| AUC0-48 h | 9020 | 4132 (45.8) |
| AUC0-∞ | 21700 | 12648 (58.3) |
apercentage of covalently bound radioactivity in plasma pellets accounting for total plasma radioactivity; Cmax, maximum drug concentration; tmax, time to maximum concentration; AUC area under the concentration-time curve