Fig. 1.

Wedelolactone (Wed) treatment reduced renal fibrosis in UUO mice. Control and UUO mice received vehicle or 30 mg/kg Wed by oral gavage once a day for 7 days. a Western blot of caspase-11, TGF-β, fibronectin, and collagen I. b Representative western blot quantification of caspase-11, TGF-β, fibronectin, and collagen I. c Ang II levels were detected using an ELISA kit. All values are presented as the mean ± SEM (n = 6). d Western blot of caspase-11, TGF-β, fibronectin, and collagen I. e Quantification of caspase-11, TGF-β, fibronectin, and collagen I. ^***P < 0.001 versus sham. ^**P < 0.01 versus sham. ^#P < 0.05 versus UUO